Rad21^tm1.1Mmk
Targeted Allele Detail

Summary

• Symbol: Rad21^tm1.1Mmk
• Name: RAD21 cohesin complex component; targeted mutation 1.1, Matthias Merkenschlager
• MGI ID: MGI:5293824
• Synonyms: Rad21^lox, Scc1^fl
• Gene: Rad21 Location: Chr15:51825636-51855143 bp, - strand Genetic Position: Chr15, 19.54 cM, cytoband D3
• Alliance: Rad21^tm1.1Mmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175827
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and an FRT-flanked puro cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the puro cassette and left exons 5 and 6 floxed. (J:175827)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad21 Mutation: 60 strains or lines available

References

• Original: J:175827 Seitan VC, et al., A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature. 2011 Aug 25;476(7361):467-71
• All: 12 reference(s)