Shh^{tm1(cre/ERT2)Tshim}
Targeted Allele Detail

Summary

• Symbol: Shh^{tm1(cre/ERT2)Tshim}
• Name: sonic hedgehog; targeted mutation 1, Tomomi Shimogori
• MGI ID: MGI:5294343
• Synonyms: Shh-IRES-Cre
• Gene: Shh Location: Chr5:28661838-28672099 bp, - strand Genetic Position: Chr5, 14.39 cM
• Alliance: Shh^{tm1(cre/ERT2)Tshim} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171106
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Shh^{tm1(cre/ERT2)Tshim} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shh (MGI:98297)

• Mutation details: Cre recombinase was inserted into the 3' end of the locus. All procedures for generating knock-in animals were performed at inGenious Targeting Laboratory (Stony Brook, NY). An internal ribosome entry site (IRES) preceding the cre coding sequence permitted expression of both Shh and cre proteins from the same mRNA. No disruption of endogenous gene activity was detected. (J:171106)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shh (mouse) Summary of all recombinase alleles driven by Shh. Alliance mouse Shh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shh Mutation: 48 strains or lines available

References

• Original: J:171106 Suzuki-Hirano A, et al., Dynamic spatiotemporal gene expression in embryonic mouse thalamus. J Comp Neurol. 2011 Feb 15;519(3):528-43
• All: 1 reference(s)