Tg(Thy1-APP*)2.2Ingm
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP*)2.2Ingm
• Name: transgene insertion 2.2, Ingenium Pharmaceuticals
• MGI ID: MGI:5294353
• Synonyms: TBA2.2
• Transgene: Tg(Thy1-APP*)2.2Ingm Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(Thy1-APP*)2.2Ingm page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP*)2.2Ingm expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into Chr. 12 at 53.5 Mbp with a 2-4 kbp deletion. No effect on the expression of neighboring genes (Heatr5a, Arhgap5 and Akap6) was detected. Maximal transgene expression was seen between P12 and P28. (J:176575)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
• All: 1 reference(s)