Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}
Transgenic Allele Detail

Summary

• Symbol: Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm}
• Name: tribbles pseudokinase 2; transgene insertion 2.1, Ingenium Pharmaceuticals
• MGI ID: MGI:5294354
• Synonyms: TBA2.1
• Gene: Trib2 Location: Chr12:15841728-15866923 bp, - strand Genetic Position: Chr12, 7.25 cM
• Alliance: Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Trib2^{Tg(Thy1-Trh/APP*)2.1Ingm} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: The Thy1 regulatory sequence directs expression of a fusion protein of the pre-pro-peptide of murine thyrotropin releasing hormone and the N terminus of the modified human amyloid beta polypeptide, Abeta(Q3?42). This transgene expresses an N terminally truncated A beta protein that is glutamate to glutamine modified at position 3 and engineered to liberate its product preferentially within the secretory pathway. Multiple copies of the transgene inserted into position 15.5-16.5 Mbp (based on NCBI Build 36 ) on chromosome 12 resulting in deletion of Trib2. Maximal transgene expression was seen between P12 and P28. (J:176575)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trib2 Mutation: 29 strains or lines available

References

• Original: J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
• All: 7 reference(s)