Qpctl^m1Ingm
Chemically induced Allele Detail

Summary

• Symbol: Qpctl^m1Ingm
• Name: glutaminyl-peptide cyclotransferase-like; mutation 1, Ingenium Pharmaceuticals
• MGI ID: MGI:5294355
• Synonyms: isoQC^-
• Gene: Qpctl Location: Chr7:18874142-18883121 bp, - strand Genetic Position: Chr7, 9.46 cM, cytoband A2
• Alliance: Qpctl^m1Ingm page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced a T to A nucleotide substitution at nucleotide position 442 leading to the introduction of a stop codon in the open reading frame terminating the protein at amino acid 144. (J:100122, J:176575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qpctl Mutation: 14 strains or lines available

References

• Original: J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
• All: 2 reference(s)