Cdkn1c^tm2.1Kei
Targeted Allele Detail

Summary

• Symbol: Cdkn1c^tm2.1Kei
• Name: cyclin dependent kinase inhibitor 1C; targeted mutation 2.1, Keiichi I Nakayama
• MGI ID: MGI:5294426
• Synonyms: p57^Flox
• Gene: Cdkn1c Location: Chr7:143012076-143014735 bp, - strand Genetic Position: Chr7, 88.22 cM
• Alliance: Cdkn1c^tm2.1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176209
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:176209)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1c Mutation: 19 strains or lines available

References

• Original: J:176209 Matsumoto A, et al., p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells. Cell Stem Cell. 2011 Sep 2;9(3):262-71
• All: 9 reference(s)