Crhr1^tm1Jde
Targeted Allele Detail

Summary

• Symbol: Crhr1^tm1Jde
• Name: corticotropin releasing hormone receptor 1; targeted mutation 1, Jan Deussing
• MGI ID: MGI:5294436
• Synonyms: Crhr1^deltaEgfp, Crhr1-EGFP
• Gene: Crhr1 Location: Chr11:104023681-104066349 bp, + strand Genetic Position: Chr11, 67.77 cM
• Alliance: Crhr1^tm1Jde page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176339
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The following elements were placed downstream and in frame of exon 2: a loxP, EGFP, self-extracting and FRT-flanked neo cassette, and an additional loxP site. The presence of the Flp gene introduces a premature stop codon and produces a truncated protein. The absence of transcript expression was confirmed by in situ hydridization on brain sections. (J:176339)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crhr1 Mutation: 28 strains or lines available

References

• Original: J:176339 Refojo D, et al., Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science. 2011 Sep 30;333(6051):1903-7
• All: 3 reference(s)