Map3k12^tm1.1Lewc
Targeted Allele Detail

Summary

• Symbol: Map3k12^tm1.1Lewc
• Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.1, Joseph W Lewcock
• MGI ID: MGI:5294468
• Synonyms: DLK^-
• Gene: Map3k12 Location: Chr15:102406079-102425311 bp, - strand Genetic Position: Chr15, 57.63 cM, cytoband F3
• Alliance: Map3k12^tm1.1Lewc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre mediated excision removed exons 2 through 5 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:176956)

Generation of the Map3k12^tm1.1Lewc allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k12 Mutation: 39 strains or lines available

References

• Original: J:176956 Ghosh AS, et al., DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
• All: 2 reference(s)