Tet3^tm1.1Gxu
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.1Gxu
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.1, Guo-Liang Xu
• MGI ID: MGI:5294563
• Synonyms: Tet3^f
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.1Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176196
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 9 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 8 and 9 floxed. (J:176196)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 60 strains or lines available

References

• Original: J:176196 Gu TP, et al., The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011 Sep 29;477(7366):606-10
• All: 7 reference(s)