Tet3^tm1.2Gxu
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1.2Gxu
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1.2, Guo-Liang Xu
• MGI ID: MGI:5294564
• Synonyms: Tet3^-
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1.2Gxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176196
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 9 via homologous recombination. Flp and Cre mediated recombination removed the neo cassette and exons 8 and 9. (J:176196)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 60 strains or lines available

References

• Original: J:176196 Gu TP, et al., The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature. 2011 Sep 29;477(7366):606-10
• All: 3 reference(s)