Scn3b^tm1Clhh
Targeted Allele Detail

Summary

• Symbol: Scn3b^tm1Clhh
• Name: sodium channel, voltage-gated, type III, beta; targeted mutation 1, Christopher LH Huang
• MGI ID: MGI:5294639
• Gene: Scn3b Location: Chr9:40180513-40202914 bp, + strand Genetic Position: Chr9, 21.42 cM
• Alliance: Scn3b^tm1Clhh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177262
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES beta-gal and neo cassette was inserted between exon 3 and 4. The absence of transcript expression was confirmed by RT-PCR on ventricular extracts. (J:177262)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn3b Mutation: 15 strains or lines available

References

• Original: J:177262 Hakim P, et al., Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties. Prog Biophys Mol Biol. 2008 Oct-Nov;98(2-3):251-66
• All: 2 reference(s)