Gstk1^tm1Pgb
Targeted Allele Detail

Summary

• Symbol: Gstk1^tm1Pgb
• Name: glutathione S-transferase kappa 1; targeted mutation 1, Philip G Board
• MGI ID: MGI:5294676
• Gene: Gstk1 Location: Chr6:42222869-42227375 bp, + strand Genetic Position: Chr6, 20.52 cM
• Alliance: Gstk1^tm1Pgb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177201
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exons 4 and 5. The absence of protein expression was confirmed by western blot analysis on liver, kidney, and heart extracts. (J:177201)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gstk1 Mutation: 17 strains or lines available

References

• Original: J:177201 Blackburn AC, et al., Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress. Lab Invest. 2011 Nov;91(11):1572-83
• All: 1 reference(s)