Cdh5^{tm3(Cdh5/Ctnna1)Dvst}
Targeted Allele Detail

Summary

• Symbol: Cdh5^{tm3(Cdh5/Ctnna1)Dvst}
• Name: cadherin 5; targeted mutation 3, Dietmar Vestweber
• MGI ID: MGI:5294790
• Synonyms: VEC-alpha-C
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^{tm3(Cdh5/Ctnna1)Dvst} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177191
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: RMCE replaced exon 2 and the neo cassette in Cdh5^tm1Dvst with a fusion of mouse Cdh5 lacking 75 C-terminal amino acids of the cytoplasmic tail and the C-terminal two-thirds of mouse alpha-catenin (amino acids 301-900), transcription stop sequence, and FRT-flanked hygro flanked by a loxP and a lox2272 site. A C to T mutation was inserted 2130 bp from the start codon to create a new ClaI site. (J:177191)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

Notes

This allele was generated from Cdh5^tm1Dvst.

References

• Original: J:177191 Schulte D, et al., Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 2011;30(20):4157-70
• All: 2 reference(s)