Cdh5^tm1Dvst
Targeted Allele Detail

Summary

• Symbol: Cdh5^tm1Dvst
• Name: cadherin 5; targeted mutation 1, Dietmar Vestweber
• MGI ID: MGI:5294807
• Gene: Cdh5 Location: Chr8:104828257-104871143 bp, + strand Genetic Position: Chr8, 53.04 cM
• Alliance: Cdh5^tm1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189010
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, RMCE-ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A neo cassette with a 3' lox2272 was inserted downstream of exon 2. (J:177191)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh5 Mutation: 59 strains or lines available

Notes

This allele was used to generate: Cdh5^{tm2(Cdh5)Dvst},Cdh5^{tm3(Cdh5/Ctnna1)Dvst}, Cdh5^{tm4(Cdh5/Fkbp,Ptprb/Mtor*)Dvst}, Cdh5^tm5Dvst, Cdh5^tm6Dvst, Cdh5^tm7Dvst, Cdh5^tm8Dvst, Cdh5^tm9Dvst.

References

• Original: J:177191 Schulte D, et al., Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 2011;30(20):4157-70
• All: 10 reference(s)