Noto^{tm1.1(cre)Csgn}
Targeted Allele Detail

Summary

• Symbol: Noto^{tm1.1(cre)Csgn}
• Name: notochord homeobox; targeted mutation 1.1, Cheryle A Seguin
• MGI ID: MGI:5294811
• Synonyms: Noto^cre
• Gene: Noto Location: Chr6:85400868-85405859 bp, + strand Genetic Position: Chr6, 37.44 cM
• Alliance: Noto^{tm1.1(cre)Csgn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177256
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Noto^{tm1.1(cre)Csgn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Noto (MGI:3053002)

• Mutation details: A targeting vector was generated to insert an IRES-NLS-cre cassette with an Frt-flanked PGK-neo sequence into the Noto locus, replacing exon 2, in G4 ES cells. Correctly targeted cells were used to produce founder chimeras that were crossed to CD1 (ICR) animals for germline transmission. Resulting animals were crossed to the Tg(ACTGLPe)9205Dym line to delete the PGK-neo. (J:177256)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Noto (mouse) Summary of all recombinase alleles driven by Noto. Alliance mouse Noto gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Noto Mutation: 15 strains or lines available

References

• Original: J:177256 McCann MR, et al., Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc development. Dis Model Mech. 2011 Jan;5(1):73-82
• All: 3 reference(s)