Hsp90aa1^tm1.1Udon
Targeted Allele Detail

Summary

• Symbol: Hsp90aa1^tm1.1Udon
• Name: heat shock protein 90, alpha (cytosolic), class A member 1; targeted mutation 1.1, Heiichiro Udono
• MGI ID: MGI:5294812
• Gene: Hsp90aa1 Location: Chr12:110657470-110662829 bp, - strand Genetic Position: Chr12, 60.75 cM
• Alliance: Hsp90aa1^tm1.1Udon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177143
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neo cassette was inserted upstream of exon 9. An additional loxP site was inserted downstream of exon 10. Cre-mediated recombination removed the neo cassette and exons 9 and 10. The absence of protein expression was confirmed by western blot analysis on liver, kidney, lung, brain, tesis, and bone marrow-derived dendritic cells. (J:177143)

Generation of the Hsp90aa1^tm1.1Udon allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsp90aa1 Mutation: 41 strains or lines available

References

• Original: J:177143 Imai T, et al., Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16363-8
• All: 4 reference(s)