Rdh10^tm2Ics
Targeted Allele Detail

Summary

• Symbol: Rdh10^tm2Ics
• Name: retinol dehydrogenase 10 (all-trans); targeted mutation 2, Mouse Clinical Institute
• MGI ID: MGI:5294929
• Synonyms: Rdh10^eGFP*
• Gene: Rdh10 Location: Chr1:16176106-16202774 bp, + strand Genetic Position: Chr1, 4.94 cM
• Alliance: Rdh10^tm2Ics page

Pleiotropic anomalies in E12.5 Rdh10^tm2Ics/Rdh10^tm2Ics mutants

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177362
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An EGFP and polyadenylation cassette was inserted at codon 191 in exon 3. A frameshift prevents the production of a functional EGFP. (J:177362)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh10 Mutation: 20 strains or lines available

References

• Original: J:177362 Rhinn M, et al., Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16687-92
• All: 1 reference(s)