Ppp1r13l^tm1.1Xlu
Targeted Allele Detail

Summary

• Symbol: Ppp1r13l^tm1.1Xlu
• Name: protein phosphatase 1, regulatory subunit 13 like; targeted mutation 1.1, Xin Lu
• MGI ID: MGI:5295045
• Synonyms: iASPP^delta8, Ppp1r13l^tm1.1Itl
• Gene: Ppp1r13l Location: Chr7:19093674-19112458 bp, + strand Genetic Position: Chr7, 9.62 cM
• Alliance: Ppp1r13l^tm1.1Xlu page

Impaired epithelial stratification in Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177360
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Cre-mediated recombination removed exon 8. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:177360)

Generation of the 5295045 allele

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ppp1r13l^tm1.1Xlu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r13l Mutation: 39 strains or lines available

References

• Original: J:177360 Notari M, et al., Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16645-50
• All: 4 reference(s)