Flt4^tm1.2Yhe
Targeted Allele Detail

Summary

• Symbol: Flt4^tm1.2Yhe
• Name: FMS-like tyrosine kinase 4; targeted mutation 1.2, Yulong He
• MGI ID: MGI:5295072
• Synonyms: Vegfr3^deltaLBD
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm1.2Yhe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177405
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 4 through 6 and the neo cassette. The predicted product lack the extracellular Ig-like domains 2 and 3 corresponding to the ligand-binding region. (J:177405)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 77 strains or lines available

References

• Original: J:177405 Zhang L, et al., VEGFR-3 ligand-binding and kinase activity are required for lymphangiogenesis but not for angiogenesis. Cell Res. 2010 Dec;20(12):1319-31
• All: 3 reference(s)