Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Rad18)Wbaa}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Rad18)Wbaa}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Willy M Baarends
• MGI ID: MGI:5295281
• Synonyms: Rad18 KD
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Rad18)Wbaa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177475
• Parent Cell Line: ART4.12 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(RNU6-RNAi:Rad18)Wbaa} involves 1 genes/genome features (Rad18) View all
• Mutation details: RMCE with Gt(ROSA)26Sor^{tm1(CAG-flpe)Arte} inserted a construct containing: an F3 site, a neomycin cassette lacking a translation initiation site (ATG), a Pgk polyadenylation signal, the human promoter driving ubiquitous expression of a short hairpin RNA against Rad18 (shRNA 20-1), and an FRT site. (J:177475)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:177475 Inagaki A, et al., Meiotic functions of RAD18. J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50
• All: 1 reference(s)