Fbxl5^tm2.1Kei
Targeted Allele Detail

Summary

• Symbol: Fbxl5^tm2.1Kei
• Name: F-box and leucine-rich repeat protein 5; targeted mutation 2.1, Keiichi I Nakayama
• MGI ID: MGI:5295289
• Synonyms: Fbxl5^F
• Gene: Fbxl5 Location: Chr5:43901958-43939529 bp, - strand Genetic Position: Chr5, 23.81 cM
• Alliance: Fbxl5^tm2.1Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176655
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An inverted neo cassette was inserted upstream of exon 4 and a loxP site was inserted downstream of exon 5 via homologous recombination. Cre mediated recombination removed the neo cassette leaving exons 4 and 5 floxed. (J:176655)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbxl5 Mutation: 45 strains or lines available

References

• Original: J:176655 Moroishi T, et al., The FBXL5-IRP2 Axis Is Integral to Control of Iron Metabolism In Vivo. Cell Metab. 2011 Sep 7;14(3):339-51
• All: 4 reference(s)