Lrrk2tm2.1Npa
Targeted Allele Detail
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Symbol: |
Lrrk2tm2.1Npa |
Name: |
leucine-rich repeat kinase 2; targeted mutation 2.1, Novartis Pharma AG |
MGI ID: |
MGI:5295371 |
Synonyms: |
LRRK2-D1994S |
Gene: |
Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
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Alliance: |
Lrrk2tm2.1Npa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:176679
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
BALB/c
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 41 was replaced with a floxed modified exon 41 with nucleotide substitutions (GAC to TCC) that result in the amino acid substitution of serine for aspartic acid at position 1994 (D1994S). An FRT-flanked neo cassette inserted downstream of the modified exon 41 was removed by flp-mediated recombination. The predicted protein is kinase dead.
(J:176679)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lrrk2 Mutation: |
159 strains or lines available
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Original: |
J:176679 Herzig MC, et al., LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet. 2011 Nov 1;20(21):4209-23 |
All: |
3 reference(s) |
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