Hcn2^tm1.2Lex
Targeted Allele Detail

Summary

• Symbol: Hcn2^tm1.2Lex
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; targeted mutation 1.2, Lexicon Genetics
• MGI ID: MGI:5295435
• Gene: Hcn2 Location: Chr10:79552468-79571942 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Hcn2^tm1.2Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176663
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by western blot analysis on brain, spinal cord, and dorsal root ganglia. (J:176663)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn2 Mutation: 31 strains or lines available

References

• Original: J:176663 Emery EC, et al., HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science. 2011 Sep 9;333(6048):1462-6
• All: 3 reference(s)