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Ightm7.1Fwa
Targeted Allele Detail
Summary
Symbol: Ightm7.1Fwa
Name: immunoglobulin heavy chain complex; targeted mutation 7.1, Frederick W Alt
MGI ID: MGI:5295442
Synonyms: 2kb-
Gene: Igh  Location: Chr12:113222388-115973574 bp, - strand  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176649
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Intragenic deletion
 
Mutation details2 kb downstream of the CTCF bingind site (CBE2) sequence in the intergenic control region 1 (IGCR1) region was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:176649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  44 strains or lines available
References
Original:  J:176649 Guo C, et al., CTCF-binding elements mediate control of V(D)J recombination. Nature. 2011 Sep 22;477(7365):424-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory