Sirt2^tm1.1Auw
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1.1Auw
• Name: sirtuin 2; targeted mutation 1.1, Johan Auwerx
• MGI ID: MGI:5295483
• Synonyms: Sirt2^flox, Sirt2^tm1.1Jmi
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1.1Auw page

Sirt2^tm1.1Auw/Sirt2^tm1.1Auw Tg(Mpz-cre)26Mes/0 mice display hypomyelination

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177468
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 5 through 7 floxed. (J:177468)

Generation of the Sirt2^tm1.1Auw allele

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 27 strains or lines available

References

• Original: J:177468 Beirowski B, et al., Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61
• All: 3 reference(s)