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Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Merck Research Laboratory
MGI ID: MGI:5295755
Synonyms: shFABP4
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177476
Parent Cell Line:  ART4.12 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
  Gt(ROSA)26Sortm3(RNAi:Fabp4)Mrl involves 1 genes/genome features (Fabp4) View all
 
Mutation detailsRMCE with Gt(ROSA)26Sortm1(CAG-flpe)Arte inserted a short hairpin RNA targeting Fabp4 into the locus. (J:177476)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:177476 Yang R, et al., RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes (Lond). 2011 Feb;35(2):217-25
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory