Gt(ROSA)26Sor^{tm3(RNAi:Fabp4)Mrl}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(RNAi:Fabp4)Mrl}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Merck Research Laboratory
• MGI ID: MGI:5295755
• Synonyms: shFABP4
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(RNAi:Fabp4)Mrl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177476
• Parent Cell Line: ART4.12 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3(RNAi:Fabp4)Mrl} involves 1 genes/genome features (Fabp4) View all
• Mutation details: RMCE with Gt(ROSA)26Sor^{tm1(CAG-flpe)Arte} inserted a short hairpin RNA targeting Fabp4 into the locus. (J:177476)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:177476 Yang R, et al., RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes (Lond). 2011 Feb;35(2):217-25
• All: 1 reference(s)