Ap2b1^{Tg(Tyr)427Ove}
Transgenic Allele Detail

Summary

• Symbol: Ap2b1^{Tg(Tyr)427Ove}
• Name: adaptor-related protein complex 2, beta 1 subunit; transgene insertion 427, Paul Overbeek
• MGI ID: MGI:5295975
• Synonyms: OVE427
• Gene: Ap2b1 Location: Chr11:83189850-83295861 bp, + strand Genetic Position: Chr11, 50.3 cM, cytoband B5
• Alliance: Ap2b1^{Tg(Tyr)427Ove} page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The 4.1 kb tyrosinase minigene (TYBS) transgene with the 2.1 kb BALB/c mouse Tyr promoter region and 2.0 kb Tyr cDNA sequence (including the stop codon polyA sequences) inserted into chromosome 11 in reverse-orientation with the left arm mapping to intron 1 and the right arm mapping to intron 14. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts, brain, and liver extracts. (J:177760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ap2b1 Mutation: 74 strains or lines available

References

• Original: J:177760 Li W, et al., EDITOR'S CHOICE: Disruption of the Murine Ap2beta1 Gene Causes Nonsyndromic Cleft Palate. Cleft Palate Craniofac J. 2010 Nov;47(6):566-73
• All: 1 reference(s)