Zc3h12a^tm1Fum
Targeted Allele Detail

Summary

• Symbol: Zc3h12a^tm1Fum
• Name: zinc finger CCCH type containing 12A; targeted mutation 1, Mingui Fu
• MGI ID: MGI:5295981
• Gene: Zc3h12a Location: Chr4:125012216-125021633 bp, - strand Genetic Position: Chr4, 58.1 cM
• Alliance: Zc3h12a^tm1Fum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176866
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 and most of exon 6 were replaced with a lacZ gene and neo cassette. The absence of protein expression was confirmed by western blot analysis on intestine, lung, and spleen extracts. (J:176866)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zc3h12a Mutation: 35 strains or lines available

References

• Original: J:176866 Liang J, et al., MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling. J Exp Med. 2010 Dec 20;207(13):2959-73
• All: 15 reference(s)