Sox2^{tm1(cre/ERT2)Hoch}
Targeted Allele Detail

Summary

• Symbol: Sox2^{tm1(cre/ERT2)Hoch}
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1, Konrad Hochedlinger
• MGI ID: MGI:5295990
• Synonyms: Sox2-Cre^ER
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^{tm1(cre/ERT2)Hoch} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177655
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sox2^{tm1(cre/ERT2)Hoch} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox2 (MGI:98364)

• Mutation details: A targeting construct encoding a cre recombinase/mutated estrogen ligand binding-domain (cre/ERT2) fusion sequence and an Frt-flanked neo cassette was targeted to the Sox2 locus in V6.5 ES cells, so that cre was under control of endogenous Sox2 regulatory elements. Chimeric mice were bred to 129/SvJae wild-type animals to test for germline transmission and to establish stable lines. (J:177655)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox2 (mouse) Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities Alliance mouse Sox2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:177655 Arnold K, et al., Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice. Cell Stem Cell. 2011 Oct 4;9(4):317-29
• All: 127 reference(s)