Map3k11^tm2.1Rjd
Targeted Allele Detail

Summary

• Symbol: Map3k11^tm2.1Rjd
• Name: mitogen-activated protein kinase kinase kinase 11; targeted mutation 2.1, Roger J Davis
• MGI ID: MGI:5296038
• Synonyms: Mlk3^deltaCRIB, Mlk3^m3cb
• Gene: Map3k11 Location: Chr19:5738770-5752893 bp, + strand Genetic Position: Chr19, 4.34 cM
• Alliance: Map3k11^tm2.1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177426
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Point mutations converting isoleucine 492 and serine 493 into alanines (Ile492Ala, Ser493Ala) were introduced into exon 7 and a floxed neo cassette was inserted via homologous recombination. Cre mediated recombination removed the neo cassette. (J:177426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k11 Mutation: 32 strains or lines available

Notes

ES cell = LC1, strain background C57BL/6J albino

References

• Original: J:177426 Kant S, et al., TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 1;25(19):2069-78
• All: 4 reference(s)