Map3k10^tm1Dsd
Targeted Allele Detail

Summary

• Symbol: Map3k10^tm1Dsd
• Name: mitogen-activated protein kinase kinase kinase 10; targeted mutation 1, Donna S Dorow
• MGI ID: MGI:5296039
• Gene: Map3k10 Location: Chr7:27355800-27374023 bp, - strand Genetic Position: Chr7, 15.95 cM
• Alliance: Map3k10^tm1Dsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177426
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 6 were replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of expression in homozygous MEFs. (J:177426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k10 Mutation: 34 strains or lines available

References

• Original: J:177426 Kant S, et al., TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011 Oct 1;25(19):2069-78
• All: 5 reference(s)