Tnip1^tm1.1Pcoh
Targeted Allele Detail

Summary

• Symbol: Tnip1^tm1.1Pcoh
• Name: TNFAIP3 interacting protein 1; targeted mutation 1.1, Philip Cohen
• MGI ID: MGI:5296045
• Synonyms: ABIN1[D485n]
• Gene: Tnip1 Location: Chr11:54801611-54853743 bp, - strand Genetic Position: Chr11, 32.13 cM
• Alliance: Tnip1^tm1.1Pcoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176826
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site was inserted upstream of exon 14. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 16. Exon 14 is modified such that a nucleotide substitution results in the amino acid substitution of asparagine for aspartic acid at position 485 (D485N). Flp-mediated recombination removed the neo cassette. (J:176826)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnip1 Mutation: 57 strains or lines available

References

• Original: J:176826 Nanda SK, et al., Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med. 2011 Jun 6;208(6):1215-28
• All: 3 reference(s)