Gata5^tm1.1Nemr
Targeted Allele Detail

Summary

• Symbol: Gata5^tm1.1Nemr
• Name: GATA binding protein 5; targeted mutation 1.1, Mona Nemer
• MGI ID: MGI:5296251
• Synonyms: Gata5^fl
• Gene: Gata5 Location: Chr2:179966926-179976492 bp, - strand Genetic Position: Chr2, 102.85 cM
• Alliance: Gata5^tm1.1Nemr page

Bicuspid aortic valve in Gata5^tm1.2Nemr/Gata5^tm1.2Nemr Tg(Tek-cre)1Ywa/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175663
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the neo cassette and left exons 3 through 6 floxed. (J:175663)

Generation of the Gata5^tm1.1Nemr and Gata5^tm1.2Nemr alleles

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gata5 Mutation: 17 strains or lines available

References

• Original: J:175663 Laforest B, et al., Loss of Gata5 in mice leads to bicuspid aortic valve. J Clin Invest. 2011 Jul 1;121(7):2876-87
• All: 2 reference(s)