Mcm10^tm1Hlee
Targeted Allele Detail

Summary

• Symbol: Mcm10^tm1Hlee
• Name: minichromosome maintenance 10 replication initiation factor; targeted mutation 1, Ho Lee
• MGI ID: MGI:5296322
• Gene: Mcm10 Location: Chr2:4995535-5017602 bp, - strand Genetic Position: Chr2, 3.12 cM, cytoband A1
• Alliance: Mcm10^tm1Hlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177618
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 4 through 6 were replaced with a puro cassette. (J:177618)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcm10 Mutation: 55 strains or lines available

References

• Original: J:177618 Lim HJ, et al., Targeted disruption of Mcm10 causes defective embryonic cell proliferation and early embryo lethality. Biochim Biophys Acta. 2011 Oct;1813(10):1777-83
• All: 1 reference(s)