Ddc^tm1.1Rhrs
Targeted Allele Detail

Summary

• Symbol: Ddc^tm1.1Rhrs
• Name: dopa decarboxylase; targeted mutation 1.1, Raymond Harris
• MGI ID: MGI:5296328
• Synonyms: Aadc^flox7
• Gene: Ddc Location: Chr11:11764101-11848144 bp, - strand Genetic Position: Chr11, 7.09 cM, cytoband A1-A4
• Alliance: Ddc^tm1.1Rhrs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exon 7 floxed. (J:175630)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ddc Mutation: 127 strains or lines available

References

• Original: J:175630 Zhang MZ, et al., Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice. J Clin Invest. 2011 Jul 1;121(7):2845-54
• All: 5 reference(s)