Nfkbib^tm1.2Rsch
Targeted Allele Detail

Summary

• Symbol: Nfkbib^tm1.2Rsch
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta; targeted mutation 1.2, Roland Schmid
• MGI ID: MGI:5296337
• Synonyms: IkappaBbeta^-
• Gene: Nfkbib Location: Chr7:28457676-28466069 bp, - strand Genetic Position: Chr7, 16.91 cM, cytoband A3-B3
• Alliance: Nfkbib^tm1.2Rsch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176877
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A floxed neomycin selection cassette was inserted in intron 3 and an additional loxP site was placed in intron 5. Cre mediated recombination resulted in removal of the neomycin selection cassette in ES cells and exons 4 and 5 in mice. (J:176877)

Generation of the Nfkbib^tm1.2Rsch allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbib Mutation: 14 strains or lines available

References

• Original: J:176877 Scheibel M, et al., IkappaBbeta is an essential co-activator for LPS-induced IL-1beta transcription in vivo. J Exp Med. 2010 Nov 22;207(12):2621-30
• All: 1 reference(s)