Brd1^tm1Hko
Targeted Allele Detail

Summary

• Symbol: Brd1^tm1Hko
• Name: bromodomain containing 1; targeted mutation 1, Haruhiko Koseki
• MGI ID: MGI:5296490
• Gene: Brd1 Location: Chr15:88571237-88618436 bp, - strand Genetic Position: Chr15, 44.17 cM
• Alliance: Brd1^tm1Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177092
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on E12.5 embryo extracts. (J:177092)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Brd1 Mutation: 120 strains or lines available

References

• Original: J:177092 Mishima Y, et al., The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis. Blood. 2011 Sep 1;118(9):2443-53
• All: 1 reference(s)