Jup^tm1.1Shou
Targeted Allele Detail

Summary

• Symbol: Jup^tm1.1Shou
• Name: junction plakoglobin; targeted mutation 1.1, Weinian Shou
• MGI ID: MGI:5296511
• Synonyms: Jup^f
• Gene: Jup Location: Chr11:100259784-100288589 bp, - strand Genetic Position: Chr11, 63.47 cM
• Alliance: Jup^tm1.1Shou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177567
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette flanked by two loxP sites and a fragment including part of Jup introns 2-6 with a third loxP site inserted into intron 5 was engineered downstream of the neomycin selection cassette. The neomycin cassette was removed by breeding with Tg(EIIa-cre)C5379Lmgd mice, leaving exons 3-5 floxed (J:177567)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jup Mutation: 162 strains or lines available

References

• Original: J:177567 Li D, et al., Restrictive loss of plakoglobin in cardiomyocytes leads to arrhythmogenic cardiomyopathy. Hum Mol Genet. 2011 Dec 1;20(23):4582-96
• All: 3 reference(s)