Cttn^tm1.1Dvst
Targeted Allele Detail

Summary

• Symbol: Cttn^tm1.1Dvst
• Name: cortactin; targeted mutation 1.1, Dietmar Vestweber
• MGI ID: MGI:5296619
• Gene: Cttn Location: Chr7:143989468-144024743 bp, - strand Genetic Position: Chr7, 88.84 cM
• Alliance: Cttn^tm1.1Dvst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177602
• Parent Cell Line: IDG3.2 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 7. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exon 7 floxed. (J:177602)

Generation of the Cttn^tm1.1Dvst and Cttn^tm1.2Dvst alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cttn Mutation: 29 strains or lines available

References

• Original: J:177602 Schnoor M, et al., Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med. 2011 Aug 1;208(8):1721-35
• All: 1 reference(s)