Aire^{tm1.1(cre)Ghr}
Targeted Allele Detail

Summary

• Symbol: Aire^{tm1.1(cre)Ghr}
• Name: autoimmune regulator; targeted mutation 1.1, Georg A Hollander
• MGI ID: MGI:5296650
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^{tm1.1(cre)Ghr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176844
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Aire^{tm1.1(cre)Ghr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aire (MGI:1338803)

• Mutation details: A cassette composed of an NLS-cre, an IRES-GFP, and an FRT flanked PGK-neomycin replaced exon 1. Flp mediated deletion in-vivo removed the neo selection cassette. (J:176844)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aire (mouse) Summary of all recombinase alleles driven by Aire. Alliance mouse Aire gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 52 strains or lines available

References

• Original: J:176844 Lei Y, et al., Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med. 2011 Feb 14;208(2):383-94
• All: 3 reference(s)