Plk4^m1Lja
Chemically induced Allele Detail

Summary

• Symbol: Plk4^m1Lja
• Name: polo like kinase 4; mutation 1, J Larry Jameson
• MGI ID: MGI:5296670
• Synonyms: line 708, Plk4^I242N
• Gene: Plk4 Location: Chr3:40754463-40771318 bp, + strand Genetic Position: Chr3, 19.54 cM
• Alliance: Plk4^m1Lja page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion in exon 5 that results in the amino acid substitution of asparagine for isoleucine at position 242 (I242N). (J:177071)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plk4 Mutation: 38 strains or lines available

References

• Original: J:177071 Harris RM, et al., Male hypogonadism and germ cell loss caused by a mutation in polo-like kinase 4. Endocrinology. 2011 Oct;152(10):3975-85
• All: 2 reference(s)