Sh3kbp1^tm1Kuro
Targeted Allele Detail

Summary

• Symbol: Sh3kbp1^tm1Kuro
• Name: SH3-domain kinase binding protein 1; targeted mutation 1, Tomohiro Kurosaki
• MGI ID: MGI:5296768
• Synonyms: CIN85^fl
• Gene: Sh3kbp1 Location: ChrX:158409888-158758916 bp, + strand Genetic Position: ChrX, 73.65 cM
• Alliance: Sh3kbp1^tm1Kuro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176805
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a floxed neomycin resistance cassette was inserted in intron 5. Excision of the selection cassette from properly trgeted clones left exon 5 flanked by loxP sites. (J:176805)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh3kbp1 Mutation: 6 strains or lines available

References

• Original: J:176805 Kometani K, et al., CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. J Exp Med. 2011 Jul 4;208(7):1447-57
• All: 2 reference(s)