Gucy1b1^tm1Zhen
Targeted Allele Detail

Summary

• Symbol: Gucy1b1^tm1Zhen
• Name: guanylate cyclase 1, soluble, beta 1; targeted mutation 1, Zhenyu Li
• MGI ID: MGI:5296786
• Synonyms: sGC beta1^fl
• Gene: Gucy1b1 Location: Chr3:81939313-81981996 bp, - strand Genetic Position: Chr3, 35.97 cM
• Alliance: Gucy1b1^tm1Zhen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177066
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 8. (J:177066)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gucy1b1 Mutation: 42 strains or lines available

References

• Original: J:177066 Zhang G, et al., Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation. Blood. 2011 Sep 29;118(13):3670-9
• All: 3 reference(s)