Tfap2d^tm1Mos
Targeted Allele Detail

Summary

• Symbol: Tfap2d^tm1Mos
• Name: transcription factor AP-2, delta; targeted mutation 1, Markus Moser
• MGI ID: MGI:5296818
• Gene: Tfap2d Location: Chr1:19173246-19236570 bp, + strand Genetic Position: Chr1, 6.08 cM
• Alliance: Tfap2d^tm1Mos page

Tfap2d^tm1Mos/Tfap2d^tm1Mos mice lack the colliculus inferior

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177585
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: Exon 1 was disrupted by the insertion of an IRES-lacZ-neo cassette. The absence of transcript expression was confirmed by RT-PCR on E17 posterior midbrain extracts. X-gal staining confirmed the expression of lacZ in the entire midbrain of newborns. (J:177585)

Generation of Tfap2d deficient mice

Expression

In Mice Carrying this Mutation:	50 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2d Mutation: 20 strains or lines available

References

• Original: J:177585 Hesse K, et al., AP-2delta is a crucial transcriptional regulator of the posterior midbrain. PLoS One. 2011;6(8):e23483
• All: 2 reference(s)