Tfap4^tm1.1Litt
Targeted Allele Detail

Summary

• Symbol: Tfap4^tm1.1Litt
• Name: transcription factor AP4; targeted mutation 1.1, Dan R Littman
• MGI ID: MGI:5296820
• Gene: Tfap4 Location: Chr16:4362525-4377718 bp, - strand Genetic Position: Chr16, 2.45 cM, cytoband A1
• Alliance: Tfap4^tm1.1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176461
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exons 2 through 4 were replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis on thymocytes. (J:176461)

Generation of Tfap4 deficient mice

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap4 Mutation: 92 strains or lines available

References

• Original: J:176461 Egawa T, et al., Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14873-8
• All: 2 reference(s)