Tg(KRT5-SRC)CJdg
Transgene Detail

Summary

• Symbol: Tg(KRT5-SRC)CJdg
• Name: transgene insertion C, John DiGiovanni
• MGI ID: MGI:5296885
• Synonyms: BK5.src^wt
• Transgene: Tg(KRT5-SRC)CJdg Location: unknown
• Alliance: Tg(KRT5-SRC)CJdg page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-SRC)CJdg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SRC (6714)

  Src	(MGI:98397)

• Tg(KRT5-SRC)CJdg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The bovine promoter drives expression of the wild-type human cDNA preceded by a rabbit beta-globin intron and followed by an SV40 polyadenylation sequence in the epidermal basal cells. Several founders were generated with only founder C surviving to produce a line. (J:85132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:85132 Matsumoto T, et al., Targeted expression of c-Src in epidermal basal cells leads to enhanced skin tumor promotion, malignant progression, and metastasis. Cancer Res. 2003 Aug 15;63(16):4819-28
• All: 2 reference(s)