Nts^tm1(cre)Mgmj
Targeted Allele Detail

Summary

• Symbol: Nts^tm1(cre)Mgmj
• Name: neurotensin; targeted mutation 1, Martin G Myers, Jr
• MGI ID: MGI:5296932
• Synonyms: Nts^Cre
• Gene: Nts Location: Chr10:102317617-102326294 bp, - strand Genetic Position: Chr10, 53.56 cM, cytoband D1
• Alliance: Nts^tm1(cre)Mgmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176657
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nts^tm1(cre)Mgmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nts (MGI:1328351)

• Mutation details: An IRES-cre sequence was inserted into the 3' UTR of the Nts gene between the stop codon and the polyadenylation sequence. A floxed neo cassette was inserted downstream of the transcribed Nts sequence. (J:176657)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nts (mouse) Summary of all recombinase alleles driven by Nts. Comparative matrix view of recombinase activities Alliance mouse Nts gene page

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nts Mutation: 18 strains or lines available

References

• Original: J:176657 Leinninger GM, et al., Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance. Cell Metab. 2011 Sep 7;14(3):313-23
• All: 35 reference(s)