Sgce^tm1Vinni
Targeted Allele Detail

Summary

• Symbol: Sgce^tm1Vinni
• Name: sarcoglycan, epsilon; targeted mutation 1, Vincenzo Nigro
• MGI ID: MGI:5296936
• Gene: Sgce Location: Chr6:4674350-4747180 bp, - strand Genetic Position: Chr6, 1.81 cM
• Alliance: Sgce^tm1Vinni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177563
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 6 through 9 were replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:177563)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sgce Mutation: 44 strains or lines available

References

• Original: J:177563 Lancioni A, et al., Combined deficiency of alpha and epsilon sarcoglycan disrupts the cardiac dystrophin complex. Hum Mol Genet. 2011 Dec 1;20(23):4644-54
• All: 1 reference(s)