Disc1^tm1Kozo
Targeted Allele Detail

Summary

• Symbol: Disc1^tm1Kozo
• Name: disrupted in schizophrenia 1; targeted mutation 1, Kozo Kaibuchi
• MGI ID: MGI:5296951
• Synonyms: Disc1^delta2-3
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^tm1Kozo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177560
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of exon 2 and all of exon 3 were replaced with a stop codon and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:177560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 69 strains or lines available

References

• Original: J:177560 Kuroda K, et al., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet. 2011 Dec 1;20(23):4666-83
• All: 6 reference(s)