Fkbp5^tm1Dvds
Targeted Allele Detail

Summary

• Symbol: Fkbp5^tm1Dvds
• Name: FK506 binding protein 5; targeted mutation 1, David F Smith
• MGI ID: MGI:5296970
• Synonyms: 51KO, Fkbp51^-
• Gene: Fkbp5 Location: Chr17:28617727-28705123 bp, - strand Genetic Position: Chr17, 14.66 cM
• Alliance: Fkbp5^tm1Dvds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101405
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:177683)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Fkbp5 Mutation: 170 strains or lines available

References

• Original: J:101405 Tranguch S, et al., Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14326-31
• All: 21 reference(s)